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Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections. |
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Wednesday, 01 June 2005 00:00 |
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“Large artery stiffness and wave reflections are important independent prognosticators of cardiovascular disease risk because they determine left ventricular function, coronary blood flow, and mechanical integrity of arteries. Although we and others previously showed that caffeine acutely increases arterial stiffness and wave reflections, the chronic effect of coffee consumption on these indexes has not been defined.”
“228 clinically healthy subjects: 141 men (41 +/- 8y old) and 87 women (41 +/- 9 y old).”
“All reported types of coffee (instant, “Greek” type, filtered, espresso, or cappuccino) were adjusted for 1 cup (150ml) of coffee and a caffeine concentration of 80 mg. According to the distrubution of coffee consumption, we categorized usual coffee consumption as none, low (< 200 mL/d), moderate (200-450 mL/d), or high (> 450 mL/d).”
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Last Updated on Wednesday, 24 June 2009 13:06 |
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Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study |
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Friday, 01 October 2004 00:00 |
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“The effect of coffee consumption on the cardiovascular system is conflicting. Inflammation is important to the development of cardiovascular disease (CVD), and several dietary factors are thought to exert significant effect on inflammation and thus on the risk of CVD.”
“The cross-sectional survey enrolled 1514 men (aged 46 +/- 13 y; range 18-87 y) and 1528 women (aged 45 +/- 13 y; range 18-89 y).”
“Studies have suggested that low-grade systemic inflammation participates in the pathophysiology of obesity, insulin resistance, ischemic heart disease, metabolic syndrome X, and abnormal coagulation process. An extensive body of scientific evidence also suggests that dietary factors exert their influence largely through their effects on blood pressure, lipids and lipoproteins, as well as on markers of inflammation and coagulation. This evidence implies that dietary intervention designed to reduce the inflammatory process could be of benefit in reducing the risk of cardiovascular disease (CVD).”
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Last Updated on Wednesday, 24 June 2009 13:05 |
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Quantifying Adverse Drug Events – Are Systematic Reviews the Answer? |
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Wednesday, 01 September 2004 00:00 |
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“The direct medical costs associated with ADEs have been estimated to be in the range of $US30 billion to $US130 billion annually in the US alone. These estimates are even more meaningful when compared with other high cost conditions or diseases, such as diabetes mellitus ($US45.2 billion), obesity ($US70 billion), and cardiovascular disease ($US199.5 billion). Drug-related mortality has been estimated to claim 218,000 lives annually.”
“The importance of quantifying ADEs is particularly apparent in the case of drug treatment for children, women of child-bearing age, and the elderly. Because these population groups are exposed to medications almost entirely in the postmarketing phase of drug use, there is no systematic examination of the outcomes of medication use as would exist if the medication were given as part of the clinical trial.”
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Last Updated on Wednesday, 24 June 2009 12:52 |
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Dietary intake of antioxidants and risk of Alzheimer disease |
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1086
(1 vote, average 5.00 out of 5)
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Thursday, 29 January 2004 00:00 |
“CONTEXT: Laboratory findings have suggested that oxidative stress may contribute to the pathogenesis of Alzheimer disease. Therefore, the risk of Alzheimer disease might be reduced by intake of antioxidants that counteract the detrimental effects of oxidative stress.”
“OBJECTIVE: To determine whether dietary intake of antioxidants is related to risk of Alzheimer disease.”
“DESIGN AND SETTING: The Rotterdam Study, a population-based, prospective cohort study conducted in the Netherlands.”
“PARTICIPANTS: A total of 5395 participants who, at baseline (1990-1993), were aged at least 55 years, free of dementia, and noninstitutionalized and had reliable dietary assessment. Participants were reexamined in 1993-1994 and 1997-1999 and were continuously monitored for incident dementia.”
“MAIN OUTCOME MEASURES: Incidence of Alzheimer disease, based on Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria and National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer Disease and Related Disorders Association (NINCDS-ADRDA) criteria, associated with dietary intake of beta carotene, flavonoids, vitamin C, and vitamin E.”
“RESULTS: After a mean follow-up of 6 years, 197 participants developed dementia, of whom 146 had Alzheimer disease. When adjustments were made for age, sex, baseline Mini-Mental State Examination score, alcohol intake, education, smoking habits, pack-years of smoking, body mass index, total energy intake, presence of carotid plaques, and use of antioxidative supplements, high intake of vitamin C and vitamin E was associated with lower risk of Alzheimer disease (rate ratios [RRs] per 1-SD increase in intake were 0.82 [95% confidence interval [CI], 0.68-0.99] and 0.82 [95% CI, 0.66-1.00], respectively). Among current smokers, this relationship was most pronounced (RRs, 0.65 [95% CI, 0.37-1.14] and 0.58 [95% CI, 0.30-1.12], respectively) and also was present for intake of beta carotene (RR, 0.49 [95% CI, 0.27-0.92]) and flavonoids (RR, 0.54 [95% CI, 0.31-0.96]). The associations did not vary by education or apolipoprotein E genotype.”
“CONCLUSION: High dietary intake of vitamin C and vitamin E may lower the risk of Alzheimer disease.”
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The Case for A GM-Free Sustainable World |
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Sunday, 15 June 2003 00:00 |
“The consistent finding from independent research and on-farm surveys since 1999 is that GM crops have failed to deliver the promised benefits of significantly increasing yields or reducing herbicide and pesticide use. GM crops have cost the United States an estimated $12 billion in farm subsidies, lost sales and product recalls due to transgenic contamination. Massive failures in Bt cotton of up to 100% were reported in India. Biotech corporations have suffered rapid decline since 2000, and investment advisors forecast no future for the agricultural sector. Meanwhile worldwide resistance to GM has reached a climax when Zambia in 2002 refused GM maize in food aid despite the threat of famine.” “Triple herbicide-tolerant oilseed rape volunteers that have combined transgenic and non-transgenic traits are now widespread in Canada. Similar multiple herbicide-tolerant volunteers and weeds have emerged in the United States. In the United States, glyphosate-tolerant weeds are plaguing GM cotton and soya fields, and atrazine, one of the most toxic herbicides, has had to be used with glufosinate-tolerant GM maize.” “The glycoprotein gene gp120 of the AIDS virus HIV-1, incorporated into GM maize as a 'cheap, edible oral vaccine', serves as yet another biological time-bomb, as it can interfere with the immune system and recombine with viruses and bacteria to generate new and unpredictable pathogens.”
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Last Updated on Wednesday, 24 June 2009 12:57 |
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